Application of a high-throughput quantitative PCR system for simultaneous monitoring of SARS-CoV-2 variants and other pathogenic viruses in wastewaterArticle Published on 2022-12-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Alpha variant analyzed application applied assays can be used collected Community coronavirus coronavirus disease COVID-19 delta variant demonstrated detect eight epidemiologically FIVE Health High-throughput qPCR highlighting increase Japan L452R labor-intensive likelihood Mie N501Y nine nucleotide nucleotide substitution pathogenic virus pathogenic viruses Pathogenic viruses, SARS-CoV-2 Patient PCR positive prevalent qPCR quantitative PCR quarantine reported RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant separated Surveillance target tested time-consuming Treatment virus viruses Volume wastewater Wastewater. Yokkaichi [DOI] 10.1016/j.scitotenv.2022.158659 PMC 바로가기
State-of-the-art and emerging antivirals for chronic hepatitis B infectionReview Published on 2022-12-012023-06-13 Journal: Expert opinion on pharmacotherapy [Category] B형 간염, [키워드] Antisense oligonucleotide capsid assembly modulator cccDNA Entry inhibitor functional cure nucleic acid polymer nucleoside nucleotide small interfering RNA. [DOI] 10.1080/14656566.2022.2144219 PMC 바로가기 [Article Type] Review
Human parainfluenza 3 and respiratory syncytial viruses detected in pangolins천산갑에서 검출된 인간 파라인플루엔자 3 및 호흡기 세포융합 바이러스Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료기술, [키워드] approaches died Diseases eight Evidence Host hRSV Human human parainfluenza virus human respiratory diseases identity Infection investigated metagenomic metagenomic sequencing nucleotide Other respiratory viruses pangolin pangolins parainfluenza parainfluenza virus Paramyxoviridae pathogen Pathogens Phylogenetic tree Pneumonia Prevent public health related viruses respiratory diseases respiratory syncytial virus respiratory syncytial virus B respiratory viruses sequence susceptible Symptom Viral transmission virus virus virus transmission virus transmission vector whole-genome zoonotic zoonotic diseases. [DOI] 10.1080/22221751.2022.2086071 PMC 바로가기 [Article Type] Article
Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent MutationsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type [DOI] 10.1128/spectrum.01219-22 PMC 바로가기
On the Recognition of Natural Substrate CTP and Endogenous Inhibitor ddhCTP of SARS-CoV-2 RNA-Dependent RNA Polymerase: A Molecular Dynamics StudyArticle Published on 2022-10-242022-11-15 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 치료제, [키워드] absence affecting Antiviral computational method COVID-19 outbreak Cryo-electron microscopy cytidine Dynamics endogenous enzyme help implication in silico information inhibitor inhibitory innate immune response investigated MD simulation mechanism molecular molecular mechanism multiple mutation natural novel coronavirus SARS-CoV-2 nucleotide pandemic Protein RdRP RdRp active site Recognition responsible RNA RNA sequence RNA-dependent RNA polymerase SARS-CoV-2 substrate viral replication virus [DOI] 10.1021/acs.jcim.2c01002 PMC 바로가기
Analysis of the mutation dynamics of SARS-CoV-2 genome in the samples from Georgia State of the United States미국 조지아주 샘플에서 SARS-CoV-2 게놈의 돌연변이 역학 분석Article Published on 2022-10-202022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Algorithm Amino acid analysis Analysis caused China clade clades Complete coronavirus disease Coronavirus disease 2019 Coronavirus-2 country Course COVID-19 D614G determine disease England Europe Filter Genome genome sequence Genome sequences Host indicate limit majority Multiple Multiple studies mutated Mutation N501Y NCBI database Novel coronavirus novel coronavirus SARS-CoV-2 nucleotide nucleotides online tool over P681H pandemic Phylogenetic Quality control reference genome SARS-CoV-2 SARS-CoV-2 genome SARS-CoV2 sequence Sequence alignment sequenced genomes sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe acute respiratory syndrome coronavirus-2. Spread state survival the United State the WHO translation Transmission variant variants virus was used Wuhan [DOI] 10.1016/j.gene.2022.146774 PMC 바로가기 [Article Type] Article
Forty Years of Molecular Diagnostics for Infectious DiseasesArticle Published on 2022-10-192022-11-15 Journal: Journal of Clinical Microbiology [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] amplification assumed Care coronavirus disease COVID-19 detect diagnostic diagnostic molecular microbiology diagnostics DNA DNA sequencing elapsed Factors Health in vitro Infectious disease Intersection knowledge Magnetic beads microbial molecular nucleic acid nucleic acids nucleotide nucleotide array pandemic pathophysiologic PCR Perspective point of care progression quantification Quantitative real-time quantitative PCR Sequencing syndromic panel. turn Year [DOI] 10.1128/jcm.02446-21 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
ATP enhances the error-prone ribonucleotide incorporation by the SARS-CoV-2 RNA polymeraseArticle Published on 2022-10-152022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Analysis ATP biochemical caused Concentration conserved contribute coronavirus 2 COVID-19 COVID-19 patients develop effective ENhance function Genome global pandemic in vitro inhibitors intrinsic nucleotide nucleotides outbreak physiological Proofreading provided replicated replication-transcription complex respiratory reveal ribonucleotide RNA RNA polymerase RNA proofreading RNA replication-Transcription complex RNA-dependent RNA polymerase robust RTC SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2. specificity Structure the SARS-CoV-2 therapeutic strategy treated [DOI] 10.1016/j.bbrc.2022.07.087 PMC 바로가기
Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19Research article Published on 2022-10-012022-10-05 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] acute respiratory syndrome Antiviral antiviral activity Antiviral treatment B.1.351 B.1.617.2 Beta Brequinar cellular Combination coronavirus coronavirus disease COVID-19 de novo deaths Delta DHODH Dihydroorotate dehydrogenase (DHODH) Dipyridamole drug treatments effective enzyme evade Evolution of SARS-CoV-2 exhibit global pandemic Host host cell in vitro Infection infections inhibitor maintain medical need monoclonal antibody nucleotide pathway rationale Replication required resulting RNA virus SARS-CoV-2 SARS-COV-2 infection selective shown Support synergistic therapy treat Treatment Vaccine variants viral replication [DOI] 10.1016/j.antiviral.2022.105403 [Article Type] Research article